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This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression. It provides perspectives from both prokaryotic and eukaryotic systems; offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression; discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation; and evaluates experimental procedures for studying mRNA degradation. Written by experts in the field, "Control of Messenger RNA Stability" serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists.