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The influence of the extracorporeal circulation on blood and tissue is still a topic with many question marks. The interaction of foreign surfaces and forces with the living system is often a cause of critical pathologic reactions in the organism which can endanger the success of a perfectly performed cardiac operation. Such results are no longer only a domain of cardiovascular surgery and definitely require the intensive cooperator of many medical and scientific branches. The concept of this book is to link the experiences and observations from the viewpoint of different disciplines and establish a joint field of knowledge in the essentials of the extracorporeal circulation. The contributions contain important information about the effects of blood-material interaction, hematological reactions and clinical aspects.§