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Hypoxia-Selective Copper Radiopharmaceuticals
Английски език
234 b
30 дни за връщане на стоката
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Solid tumours differ from normal tissue in a number§of important ways. Rapid growth and metabolism of§tumours often leads to altered physiology including§changes in vasculature and perfusion which can in§turn induce fluctuations in the supply of nutrients§such as oxygen. Reduced tissue oxygenation, known as§hypoxia, has been linked to radio- and§chemotherapeutic resistance and is often associated§with a poor prognosis for disease-free survival in§cancer patients. §§Identification of tumour hypoxia by using§non-invasive imaging techniques such as positron§emission tomography (PET) is vital for clinicians to§provide effective treatment. However, physiological§imaging modalities such as PET require the design and§administration of radioactive imaging agents which§specifically target tumours. §§This book provides a background to the basic chemical§concepts and methods used in the rational design of§tumour-selective radiopharmaceuticals with particular§emphasis on the mechanisms by which§copper-based imaging agents target tumour hypoxia.
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Английски език
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