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The aim of this authoritative book is to summarize current knowledge on the cellular and molecular aspects of the ageing immune system and their clinical relevance. All areas of immunosenescence are covered, with contributions from experts in the research and clinical fields. Age-related changes in cell populations and their significance are closely examined, and attention is drawn to physiological aspects associated with the immune system, such as endocrine alterations and hormonal changes. The immunogenetics of ageing is discussed, and new information is provided on the genetic factors involved in ageing. Later chapters with a greater clinical focus highlight especially the relationship of the immune system to various diseases and disorders in the elderly, and the role of nutrition is also explored. This book will be of value to all clinical immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.