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This volume was commissioned by the International Union of Crystallography (IUCr) in recognition of the extraordinary contributions that knowledge of macromolecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell, and to the growing field of structural genomics§Covers all stages of a crystallographic analysis from the preparation of samples using the techniques of molecular biology, through crystallization, diffraction data collection, phase determination, structure validation and structure analysis§Provides key information on the fundamentals, history and current perspectives of macromolecular crystallography, as well as the availability of useful programs and databases including the Protein Data Bank - an online resource for Studying Biological Macromolecules