Models and time series analysis for anaesthesia

Nowadays, physiological monitoring is imperative for §the safety of medical operations. However, systems §which monitor the depth of anaesthesia are still far §from reliable, such that still some patients may §experience the trauma of remaining conscious under §general anaesthesia during surgery. To tackle this §problem, an interdisciplinary project "Brain §Respiration and Cardiac Causalities in Anaesthesia §(BRACCIA)" was created. The main objective of this §project was to establish how the couplings between §the cardiac, respiratory and cortical oscillations §change in anaesthesia. Under the framework of this §project, our objectives were: 1) The detection of §the deep-light change of anaesthesia from §experimental recordings on rats, and furthermore, §the investigation of the interdependencies among §three physiological activities, namely, the cardiac §activity (H), respiration (R) and cortical §activities (B) from experimental recordings of rats §and humans, for each state of the depth of §anaesthesia. 2) The modelling of the slow brain §waves, and to consider the effect of anaesthesia on §this model. This monograph explains in §detail our methods and obtained results.