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The t(4;14) translocation, present in ca. 20% of§cases of Multiple §Myeloma, results in the dysregulation of two§potential oncogenes, §MMSET and FGFR3, via juxtaposition to regulatory§elements of the IgH §locus. The presence of t(4;14) and overexpression of§transcripts from §the MMSET locus are adverse prognostic factors in§Multiple Myeloma §irrespective of FGFR3 expression, implicating MMSET§in disease §pathogenesis. MMSET is a biologically active§transcriptional effector §that could mediate a series of repressive changes by§acting as a §methyltransferase enzyme in chromatin remodeling and§as a complex §adaptor in the recruitment of repressor species.